Huperzine A is a food additive extracted from the Chinese club moss Huperzia serrata. It is gaining attention as a potential supplement or drug for treating Alzheimer's disease.
The pharmacological action of Huperzine A is similar to that of cholinesterase inhibitors, which are a class of drugs that can improve neurotransmitter levels in the brain. Early small-scale studies have shown that Huperzine A can improve memory and protect neurons, thereby slowing cognitive decline in Alzheimer's patients. However, further research is needed to clarify the true efficacy and long-term risks of Huperzine A.
Currently, most doctors do not recommend taking Huperzine A because many cholinesterase inhibitors that have been clinically validated are available, with proven safety and efficacy. For patients already taking cholinesterase inhibitors (such as donepezil, rivastigmine, galantamine, etc.), experts also do not recommend adding Huperzine A. The combination of these drugs may cause side effects such as nausea, vomiting, diarrhea, dizziness, and muscle tremors.