Atorvastatin is known for its high-intensity reduction of low-density lipoprotein cholesterol (LDL-C). Even at a low dose of 10mg, it can reduce LDL-C by more than 30%, and at higher doses (40mg), the reduction can exceed 50%. In Western countries, the maximum recommended dose of atorvastatin is 80mg, but in China, the sensitivity to the drug generally limits the recommended dose to 40mg.
Atorvastatin has a half-life of up to 14 hours, with its effective duration lasting between 20 to 30 hours. Its absorption and metabolism are not affected by food, providing flexibility in administration as it can be taken before or after meals.
Primarily metabolized in the liver, atorvastatin has minimal impact on kidney function. Even patients with renal insufficiency usually do not require dose adjustments. Studies suggest that atorvastatin helps protect blood vessels, reduce cardiovascular mortality, and does not negatively affect kidney function.
Among statin drugs, atorvastatin is unique in its mild promotion of uric acid excretion, making it advantageous for patients with hyperuricemia.
In addition to its lipid-lowering effects, atorvastatin stabilizes atherosclerotic plaques and reduces the risk of cardiovascular events. Long-term use of atorvastatin can alleviate chronic inflammation of the vascular endothelium, thereby protecting against atherosclerosis.