Statins work by inhibiting cholesterol synthesis in the liver, thereby lowering low-density lipoprotein cholesterol (LDL-C) levels in the blood. Upon discontinuation, cholesterol synthesis may return to its original level, leading to an increase in LDL-C.
As LDL-C levels rise, the risk of cardiovascular disease may also increase, especially in patients with a history of heart disease or high-risk factors.
Long-term cholesterol control helps slow the progression of atherosclerosis. Stopping statins could accelerate the advancement of atherosclerosis.
Long-term statin therapy helps stabilize and potentially reverse arterial plaques. Discontinuing the medication may result in the loss of these therapeutic benefits.
After stopping statins, there may be a reduction in the previously elevated liver enzyme levels or muscle symptoms caused by the medication.
Some studies suggest that statins may be associated with a reduced risk of new-onset diabetes. Discontinuing the medication might affect this risk.
Stopping statins may impact other cardiovascular health indicators, such as triglyceride levels and high-density lipoprotein cholesterol (HDL-C) levels.