Gallstones and chronic cholecystitis are major risk factors for gallbladder cancer because they can lead to prolonged irritation of the gallbladder wall, increasing the risk of cancer.
Women have a higher risk of developing gallbladder cancer than men, which may be related to hormone levels in women.
Gallbladder cancer is more common in people over 50, with the risk increasing with age.
Obesity and metabolic syndrome, such as type 2 diabetes, are associated with an increased risk of gallbladder cancer, possibly due to their link to chronic cholecystitis and gallstones.
People with a family history of gallbladder cancer have a higher risk of developing the disease.
Chronic pancreatitis may increase the risk of gallbladder cancer.